Immunology of Schistosomiasis

  title={Immunology of Schistosomiasis},
  author={Margaret M. Mentink-Kane and Michael H. Hsieh},
Parasitic Schistosoma worms interact with their human hosts at every stage of infection. During skin penetration, the larval stage infective for humans, cercariae secrete proteins, which modulate host immune responses. Schistosomulae, the immature stage derived from cercariae, use additional proteins to alter the biology of specific leukocyte subsets. Egg antigens and glycolipids trigger formation of granulomas, chronic macrophage-based collections of leukocytes, during schistosomiasis. These… CONTINUE READING