Immunology highlights from the recent literature

  • Published 2002 in Nature Immunology

Abstract

T cell activation is regulated by signals provided by CD28 and CTLA-4, which bind to B7 expressed by antigen-presenting cells (APCs). Whereas CD28 is constitutively expressed by T cells and enhances proliferation, CTLA-4 is localized mainly in the endosomal compartment and suppresses T cell expansion. In Immunity, Egen and Allison tracked the movement of… (More)
DOI: 10.1038/ni0302-219

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