Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff

@article{Kaufmann2008ImmunologysFT,
  title={Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff},
  author={Stefan H. E. Kaufmann},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={705-712}
}
  • S. Kaufmann
  • Published 1 July 2008
  • Biology, Medicine
  • Nature Immunology
One hundred years ago the birth of immunology was made official by the Nobel Prize award to Elie Metchnikoff and Paul Ehrlich. Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity. Ehrlich described the side-chain theory of antibody formation and the mechanisms of how antibodies neutralize toxins and induce bacterial lysis with the help of complement and thus is considered one of the… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
The Collected Papers of Paul Ehrlich
  • J. Fruton
  • Computer Science
  • The Yale Journal of Biology and Medicine
  • 1957
TLDR
Although his studies on immune reactions and on chemotherapy came after 1890, the earlier work was no less important, since it included his research on the use of aniline dyes for hematological and bacteriological staining, for the study of biochemical reactions, and for the examination of pathological tissues and fluids. Expand
The clonal selection theory: 50 years since the revolution
TLDR
This short article revolutionized the field of immunology and revolutionized clonal selection theory, according to Frank Macfarlane Burnet. Expand
Ueber eine Sprosspilzkrankheit der Daphnien. Beitrag zur Lehre über den Kampf der Phagocyten gegen Krankheitserreger
  • Elias Metschnikoff
  • Philosophy
  • Archiv für pathologische Anatomie und Physiologie und für klinische Medicin
  • 2006
A propos d'une maladie fongique des daphnies. Contribution a l'etude de la lutte des phagocytes contre les agents pathogenes.
Ueber den Kampf der Zellen gegen Erysipel-kokken
  • Dr. Elias Metschnikoff
  • Biology
  • Archiv für pathologische Anatomie und Physiologie und für klinische Medicin
  • 2005
TLDR
Die ermittelte Thatsache bot indessen ihrem Autor nichts Besonderes dar, zumal die Bakterien gegeniiber den Leucocyten sich ebenso verhielten, wie iiberhaupt alle ,rein molecnlaren K6rper, welche in die Circulation gelangen. Expand
"A Theory of the Structure and Process of Formation of Antibodies" (pages 26-32)
The citation for the published article is: Pauling, Linus. "A Theory of the Structure and Process of Formation of Antibodies." Journal of the American Chemical Society 62 (1940): 2643-2657.
The Nature of Man: Studies in Optimistic Philosophy
PROF. METCHNIKOFF'S work is already known to many; it has been widely read in previous editions, and, now that it is offered in an English version, will become still more widely known. The greatExpand
An experimental investigation of the rôle of the blood fluids in connection with phagocytosis
It is still a matter of uncertainty whether the blood fluids perform any rôle in connection with phagocytosis. Certain facts suggest that the rôle of the blood fluids, if it comes into considerationExpand
The Structure of Scientific Revolutions
A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted,Expand
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