Immunology: When lymphocytes run out of steam

  title={Immunology: When lymphocytes run out of steam},
  author={Andr{\'e} Veillette and Dominique Davidson},
The finding that absence of the enzyme CTPS1 underlies a form of human immunodeficiency highlights the role of metabolism in immune responses and suggests avenues for treating diseases such as leukaemia. See Letter p.288 A study of several unrelated families susceptible to recurrent viral diseases but in whom known primary immunodeficiencies had been excluded has led to the identification of a novel human inherited immunodeficiency, and the recognition of a molecular pathway required to mount… 

Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice

Findings implicate these two sets of proteins in the pathogenesis and maintenance of immunodeficiency in mouse AdMSCs and SCID mice.

Biomarkers of HIV associated malignancies and of drug interaction between anti-retrovirals (ARVs) and chemotherapy

This chapter discusses literature review in the context of climate change, which has changed in recent years from being primarily concerned with drought to being concerned with warming temperatures.



CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

A loss-of-function homozygous mutation in CTPS1 in humans that causes a novel and life-threatening immunodeficiency, characterized by an impaired capacity of activated T and B cells to proliferate in response to antigen receptor-mediated activation is identified.

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

It is becoming increasingly clear that T cell function is intimately linked to metabolic programs, and as such there is a considerable and growing interest in developing techniques that target metabolism for immunotherapy.

The enigmatic cytoophidium: Compartmentation of CTP synthase via filament formation

  • Ji-Long Liu
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2011
Findings indicate that the cytoophidium is highly conserved in a wide range of organisms, across prokaryotes and eukaryotes.

Mammalian Pyrimidine Biosynthesis: Fresh Insights into an Ancient Pathway*

This review focuses on the structure and regulation of the pyrimidine biosynthetic complexes and the interplay of the diverse control mechanisms operative in mammalian cells.

Regulation of Human Cytidine Triphosphate Synthetase 2 by Phosphorylation*

This study determined the kinetic properties of the individual human CTPS isozymes (hCTPS1 and hCTPS2) and regulation through substrate concentration, oligomerization, and phosphorylation and identified Ser568 as a major site of CTPS2 regulation by phosphorylated.

Regulation of Human Cytidine Triphosphate Synthetase 1 by Glycogen Synthase Kinase 3*

This is the first study to investigate the phosphorylation and regulation of human CTPS1 in human cells and suggests that GSK3 is a novel regulator of CTPS activity.

Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine.

The finding that the inhibition of the in vitro growth of leukemia L1210 cells by deaza-UR is reversed by cytidine and to a lesser extent by uridine and 2′-deoxycytidine, but not by thymidine or 2′ -deoxyuridine, suggests that deazuridine exerts its growth-inhibitory activity by interfering with the activity of the cytidine triphosphate synthetase.