Immunologically Active Autoantigens : The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

@inproceedings{Rooney2009ImmunologicallyAA,
  title={Immunologically Active Autoantigens : The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease},
  author={Cliona M Rooney and Aaron Edward Foster and Dmitry I Gabrilovich and Eduardo M. Sotomayor and Kim E Nichols and Stuart G Tangye and Michelle Krogsgaard and Morgan Huse},
  year={2009}
}
Pattern recognition receptors (PRRs), expressed on cells of both the innate and adaptive immune systems, serve as sentinels, waiting to alert the host to the first signs of microbial infection and to activate the initial line of immune defense. Research has increasingly demonstrated that many of the same PRRs also recognize self-epitopes that either are released from dying or damaged cells or are present at the surface of apoptotic cells or apoptotic bodies. In this context, PRRs play a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 144 extracted citations

Immunology of the ocular surface.

The Veterinary clinics of North America. Small animal practice • 2008
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 117 references

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

The Journal of clinical investigation • 2005
View 20 Excerpts
Highly Influenced

A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 2 Excerpts

Similar Papers

Loading similar papers…