Immunological tolerance and autoimmunity

@article{Romagnani2006ImmunologicalTA,
  title={Immunological tolerance and autoimmunity},
  author={Sergio Romagnani},
  journal={Internal and Emergency Medicine},
  year={2006},
  volume={1},
  pages={187-196}
}
  • S. Romagnani
  • Published 2006
  • Medicine
  • Internal and Emergency Medicine
Immunological tolerance is a complex series of mechanisms that impair the immune system to mount responses against self antigens. Central tolerance occurs when immature lymphocytes encounter self antigens in the primary lymphoid organs, and consequently they die or become unreactive. Peripheral tolerance occurs when mature lymphocytes, escaped from negative selection during ontogeny, encounter self antigens in secondary lymphoid organs and undergo anergy, deletion or suppression. A… Expand
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