Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

@article{RiolBlanco2009ImmunologicalSF,
  title={Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells},
  author={Lorena Riol-Blanco and Cristina Delgado-Mart{\'i}n and Noelia S{\'a}nchez-S{\'a}nchez and Luis M Alonso-C and Mar{\'i}a Dolores Guti{\'e}rrez-L{\'o}pez and Gloria Mart{\'i}nez del Hoyo and Joaqu{\'i}n Navarro and Francisco S{\'a}nchez-Madrid and Carlos Caba{\~n}as and Paloma S{\'a}nchez-Mateos and Jos{\'e} Luis Rodr{\'i}guez-Fern{\'a}ndez},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={753-760}
}
The immunological synapse (IS) is a cell–cell junction formed between CD4+ T cells and dendritic cells (DCs). Here we show in vitro and in vivo that IS formation inhibits apoptosis of DCs. Consistent with these results, IS formation induced antiapoptotic signaling events, including activation of the kinase Akt1 and localization of the prosurvival transcription factor NF-κB and the proapoptotic transcription factor FOXO1 to the nucleus and cytoplasm, respectively. Inhibition of… CONTINUE READING

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