Immunological surveillance of tumors in the context of major histocompatibility complex restriction of T cell function.

@article{Doherty1984ImmunologicalSO,
  title={Immunological surveillance of tumors in the context of major histocompatibility complex restriction of T cell function.},
  author={Peter C. Doherty and Barbara B Knowles and Peter J. Wettstein},
  journal={Advances in cancer research},
  year={1984},
  volume={42},
  pages={1-65}
}
The immunological surveillance hypothesis was formulated prior to the realization of the fact that an individual's effector T cells generally only see neoantigen if it is appropriately presented in the context of self MHC glycoproteins. The biological consequence of this mechanism is that T lymphocytes are focused onto modified cell-surface rather than onto free antigen. The discovery of MHC-restricted T cell recognition, and the realization that T cell-mediated immunity is of prime importance… CONTINUE READING
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