Immunological studies of aging. II. Loss of IgG and high avidity plaque- forming cells and increased suppressor cell activity in aging mice

@article{Goidl1976ImmunologicalSO,
  title={Immunological studies of aging. II. Loss of IgG and high avidity plaque- forming cells and increased suppressor cell activity in aging mice},
  author={Edmond A. Goidl and Jennifer Innes and Marc E. Weksler},
  journal={The Journal of Experimental Medicine},
  year={1976},
  volume={144},
  pages={1037 - 1048}
}
The magnitude and heterogeneity of the immune response to dinitrophenylated bovine gamma globulin was measured in aged and young mice at a cellular level using an inhibition of plaque-forming cell assay. The primary and secondary responses of 24-mo-old mice were markedly depressed in magnitude and restricted in avidity for the DNP determinant when compared to 2-mo-old animals. Bacterial lipopolysaccharide given at the time of immunization increased the restriction in heterogeneity seen in 12… CONTINUE READING

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Assays for antibody-producing cells

  • D. W. Dresser, M. F. Greaves
  • editor. Blackwell Scientific Publications,
  • 1973

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