Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection.

@article{Murtaugh2002ImmunologicalRO,
  title={Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection.},
  author={Michael Murtaugh and Zhengguo Xiao and Federico A. Zuckermann},
  journal={Viral immunology},
  year={2002},
  volume={15 4},
  pages={533-47}
}
The immunology of porcine reproductive and respiratory syndrome virus (PRRS) begins with an initial encounter of PRRSV with the pig. Regardless of the route of entry of PRRSV--via inhalation, intramuscular vaccination, insemination, or other routes--productive infection occurs predominately in alveolar macrophages of the lung. Thus, innate responses of the lung and the alveolar macrophage comprise the initial defense against PRRSV. The virus appears not to elicit innate interferon and cytokine… CONTINUE READING