Immunological properties of plaque purified strains of live attenuated respiratory syncytial virus (RSV) for human vaccine.

@article{Herlocher1999ImmunologicalPO,
  title={Immunological properties of plaque purified strains of live attenuated respiratory syncytial virus (RSV) for human vaccine.},
  author={Martha Louise Herlocher and Mary Elizabeth. Ewasyshyn and Suryaprakash Sambhara and Mehrnaz Gharaee-Kermani and Daeho J Cho and Jun F Lai and Michel C. A. Klein and Hunein F. Maassab},
  journal={Vaccine},
  year={1999},
  volume={17 2},
  pages={
          172-81
        }
}
Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants, young children, and the elderly. Efforts to develop satisfactory live or inactivated vaccines have not yet been proven successful. Our research focuses on the development of four purified live attenuated RSV sub-type A human vaccine clones. Temperature sensitive (ts) and attenuated purified clones of either cold-adapted (ca) RSV or high-passage (hp) RSV were administered intra-nasally (i.n.) to BALB/c… CONTINUE READING
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