Immunological processes in malaria pathogenesis

@article{Schofield2005ImmunologicalPI,
  title={Immunological processes in malaria pathogenesis},
  author={Louis Schofield and Georges E. R. Grau},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={722-735}
}
Malaria is possibly the most serious infectious disease of humans, infecting 5–10% of the world's population, with 300–600 million clinical cases and more than 2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial, but incomplete, protection against pathogen replication; however, these complex immunological reactions can contribute to disease and fatalities. So, appropriate regulation of immune responses to malaria lies at… 
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627 Citations
Highly Influential Citations
36
Background Citations
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627 Citations

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Intravascular infiltrates and organ‐specific inflammation in malaria pathogenesis
  • L. Schofield
  • Medicine, Biology
    Immunology and cell biology
  • 2007
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This review addresses the view that immunopathology in severe malaria arises predominantly from intravascular lesions resulting from a pathogen‐initiated cascade of activated immune effector and regulatory cells infiltrating the vascular beds of diverse target organs, including bone marrow, spleen, brain, placenta and lungs.
...
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References

SHOWING 1-10 OF 148 REFERENCES
Clinical features and pathogenesis of severe malaria.
The importance of the spleen in malaria.
Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans
TLDR
It is proposed that some pathogenic mechanisms, drawn from data obtained from experiments in a mouse model, may be instrumental in humans, implying that the transmembrane form of TNF may be more important than the soluble form of the cytokine.
Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines
TLDR
The latest advances in the development of a vaccine that specifically targets pregnancy-associated malaria (PAM) are discussed, with more immediate prospects for vaccines that protect against specific disease syndromes.
Pathophysiology of Cerebral Malaria
TLDR
A novel mechanism of cytoadhesion may reorient the sequestration of different parasite phenotypes and play an important role in the pathogenesis of severe malaria.
Inhibition of Platelet Adherence to Brain Microvasculature Protects against Severe Plasmodium berghei Malaria
TLDR
Findings support the hypothesis that inhibition of platelet adhesion to the brain microvasculature protects against development of malarial pathogenesis.
Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion.
TLDR
A novel mechanism of cytoadhesion may reorient the sequestration of different parasite phenotypes and play an important role in the pathogenesis of severe malaria.
Immunity to non-cerebral severe malaria is acquired after one or two infections
TLDR
The number of prior infections needed to reduce the risk of severe disease to negligible levels is estimated, contrary to expectations, one or two successful infective bites seem to be all that is necessary across a broad range of transmission intensities.
The Natural Killer Complex Regulates Severe Malarial Pathogenesis and Influences Acquired Immune Responses to Plasmodium berghei ANKA
TLDR
It is shown that during murine malaria infection, the NKC regulates a range of pathophysiological syndromes such as cerebral malaria, pulmonary edema, and severe anemia, which contribute to morbidity and mortality in human malaria.
On the Pathogenic Role of Brain-Sequestered αβ CD8+ T Cells in Experimental Cerebral Malaria1
TLDR
It is demonstrated that CD8+ αβ T cells, which sequester in the brain at the time when neurological symptoms appear, were responsible for CM mortality, suggesting a mechanism which unifies disparate observations in humans.
...
...