Immunological paralysis to pneumococcal polysaccharide in man.

  title={Immunological paralysis to pneumococcal polysaccharide in man.},
  author={Michael E. Pichichero},
  volume={2 8453},
A 9-month-old infant had severe pneumococcal meningitis and for the next two years showed immunological paralysis to the causal serotype. He remained normally responsive to a protein antigen (tetanus toxoid) and to polysaccharide antigens (Haemophilus influenzae type b capsule and pneumococcal capsule antigens other than the infecting/paralysing serotype). By the fourth year of life the child was spontaneously producing antibody to the infecting/paralysing pneumococcal serotype, at which time… CONTINUE READING