Immunological paralysis to pneumococcal polysaccharide in man.

@article{Pichichero1985ImmunologicalPT,
  title={Immunological paralysis to pneumococcal polysaccharide in man.},
  author={Michael E. Pichichero},
  journal={Lancet},
  year={1985},
  volume={2 8453},
  pages={468-71}
}
A 9-month-old infant had severe pneumococcal meningitis and for the next two years showed immunological paralysis to the causal serotype. He remained normally responsive to a protein antigen (tetanus toxoid) and to polysaccharide antigens (Haemophilus influenzae type b capsule and pneumococcal capsule antigens other than the infecting/paralysing serotype). By the fourth year of life the child was spontaneously producing antibody to the infecting/paralysing pneumococcal serotype, at which time… CONTINUE READING