Immunological mechanisms of allergen-specific immunotherapy

  title={Immunological mechanisms of allergen-specific immunotherapy},
  author={Mark Larch{\'e} and Cezmi A. Akdis and Rudolf Valenta},
  journal={Nature Reviews Immunology},
Allergen-specific immunotherapy has been carried out for almost a century and remains one of the few antigen-specific treatments for inflammatory diseases. The mechanisms by which allergen-specific immunotherapy exerts its effects include the modulation of both T-cell and B-cell responses to allergen. There is a strong rationale for improving the efficacy of allergen-specific immunotherapy by reducing the incidence and severity of adverse reactions mediated by IgE. Approaches to address this… CONTINUE READING
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