Immunological mechanism underlying the immune response to recombinant human protein therapeutics.

@article{Sauerborn2010ImmunologicalMU,
  title={Immunological mechanism underlying the immune response to recombinant human protein therapeutics.},
  author={Melody Sauerborn and Vera Brinks and Wim Jiskoot and Huub Schellekens},
  journal={Trends in pharmacological sciences},
  year={2010},
  volume={31 2},
  pages={53-9}
}
Recombinant human (rhu) protein therapeutics are powerful tools to treat several severe diseases such as multiple sclerosis and diabetes mellitus, among others. A major drawback of these proteins is the production of anti-drug antibodies (ADAs). In some cases, these ADAs have neutralizing capacity and can interfere with the efficacy and safety of the drug. Little is known about the immunological mechanisms underlying the unwanted immune response against human homolog protein therapeutics. This… CONTINUE READING

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