Immunological identification of Trypanosoma cruzi lineages in human infection along the endemic area.

@article{Risso2011ImmunologicalIO,
  title={Immunological identification of Trypanosoma cruzi lineages in human infection along the endemic area.},
  author={Marikena G. Risso and Paula Sartor and Juan Miguel Burgos and Luis Miguel Ca{\~n}izalez Brice{\~n}o and Eva M. Rodriguez and Felipe Guhl and Omar Triana Ch{\'a}vez and Berta Espinoza and Victor Monte{\'o}n and Graciela Russomando and Alejandro G Schijman and Oscar Adelmo Bottasso and Maria Leguizam{\'o}n},
  journal={The American journal of tropical medicine and hygiene},
  year={2011},
  volume={84 1},
  pages={
          78-84
        }
}
Genotyping studies show a polarized geographic distribution of Trypanosoma cruzi lineages in humans. Here, we assessed their distribution along Latin America through an immunological approach we designated Western blot (WB) assay with Trypomastigote small-surface antigen (TSSA) I and TSSA II (TSSA-WB). These antigens are expressed by T. cruzi I (TCI; now TcI) and T. cruzi II (TCII; reclassified as TcII to TcVI) parasites. TSSA-WB showed good concordance with genotyping tests. An unexpected… CONTINUE READING

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