Immunological evaluation of vestibular folds in autopsies of patients with the acquired immunodeficiency syndrome.

Abstract

UNLABELLED Immune response cells are decreased in patients with the Acquired Immunodeficiency Syndrome. This alters the cell population in vestibular fold lymphoid follicles, leading to respiratory infections in these patients. Such infections are the main cause of mortality and morbidity in these patients. AIM to characterize lymphoid follicle cell populations in the vestibular folds of adults with the Acquired Immunodeficiency Syndrome and associated or not respiratory infection. MATERIALS AND METHODS A retrospective study was made of 64 adult larynges harvested during routine autopsies. Anti-B cell, Anti-CD3, Anti-CD68 and Anti-follicular dendritic cell antibodies were used for immunological testing. RESULTS 46 (71.87%) of the sample patients had the Acquired Immunodeficiency Syndrome. In these patients, lymphoid follicle cellularity was lower compared to the control group. The cell number was decreased in patients with the Acquired Immunodeficiency Syndrome and associated respiratory tract infection. CONCLUSION We demonstrated in this study that vestibular fold lymphoid follicles were affected by viral infections, and may be considered as a reliable marker of immunodepression in these patients.

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Cite this paper

@article{Olegrio2008ImmunologicalEO, title={Immunological evaluation of vestibular folds in autopsies of patients with the acquired immunodeficiency syndrome.}, author={Jana{\'i}nna Grazielle Pacheco Oleg{\'a}rio and Renata Calciolari Rossi and Ana Karina Marques Salge and Rosana Rosa Miranda C{\^o}rrea and Vicente de Paula Antunes Teixeira and E C C Castro}, journal={Brazilian journal of otorhinolaryngology}, year={2008}, volume={74 3}, pages={363-8} }