Immunological evaluation of urinary trypsin inhibitors in blood and urine: Role of N- & O-linked glycoproteins

@article{Pugia2006ImmunologicalEO,
  title={Immunological evaluation of urinary trypsin inhibitors in blood and urine: Role of N- & O-linked glycoproteins},
  author={Michael J. Pugia and Saeed A. Jortani and Manju Basu and Ronald Sommer and Hai-Hang Kuo and Solomon Murphy and Doug Williamson and James Nicholas Vranish and Patrick J. Boyle and Danny Budzinski and Roland Valdes and Subhash C. Basu},
  journal={Glycoconjugate Journal},
  year={2006},
  volume={24},
  pages={5-15}
}
Urinary trypsin inhibitors (uTi) suppress serine proteases during inflammation. After liberation from proinhibitors (P-alpha-I and I-alpha-I) by the white blood cell (WBC) response, uTi readily pass through the kidneys into urine. A key uTi, bikunin, is attached to O-linked and N-linked glycoconjugates. Recently, uTi inhibitors, called uristatins, were found to lack the O-linked glycoconjugates. Monoclonal antibodies were produced using purified uristatin and screened for binding differences to… CONTINUE READING
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