Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes.

@article{Graeler2005ImmunologicalEO,
  title={Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes.},
  author={Markus H. Graeler and M. Gibbs R. Goldberg T. Hirokawa A. H. C. Huang and Susan R. Watson and Edward J. Goetzl},
  journal={Journal of immunology},
  year={2005},
  volume={174 4},
  pages={1997-2003}
}
The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) normally transduces S1P effects on lymph node (LN) egress and tissue migration of naive lymphocytes. We now show that persistent expression of S1P1 by lymphocytes of S1P1-transgenic (Tg) mice suppresses delayed-type hypersensitivity and results in production of significantly more IgE… CONTINUE READING