Immunological effects of chlorinated dibenzo-p-dioxins.

  title={Immunological effects of chlorinated dibenzo-p-dioxins.},
  author={Nancy I Kerkvliet},
  journal={Environmental Health Perspectives},
  pages={47 - 53}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally similar halogenated aromatic hydrocarbons cause a broad range of immunologic effects in experimental animals including decreased host resistance to infectious disease and suppressed humoral and cell-mediated immune responses. In the mouse, TCDD immunotoxicity has been shown to be an aryl hydrocarbon (Ah) receptor-dependent process. However, despite considerable research, the biochemical and molecular alterations that occur subsequent… CONTINUE READING