Immunological effects of allopurinol in the treatment of experimental autoimmune uveitis (EAU) after onset of the disease.

@article{Grus2003ImmunologicalEO,
  title={Immunological effects of allopurinol in the treatment of experimental autoimmune uveitis (EAU) after onset of the disease.},
  author={Franz Herman Grus and Albert J. Augustin and Kim Loeffler and Joachim Lutz and Norbert Pfeiffer},
  journal={European journal of ophthalmology},
  year={2003},
  volume={13 2},
  pages={185-91}
}
PURPOSE Allopurinol reduces oxidative tissue damage and exerts immunomodulating effects in the treatment of experimental autoimmune uveitis (EAU). However, the mechanism of the immunologic pathway remains unclear. In previous studies, treatment was started at the time of immunization. Therefore, whether allopurinol prevents the onset of the disease (i.e., acts in a protective manner) is not known. METHODS Sixteen male Lewis rats were used: 6 EAU without therapy [control]; 4 EAU with… CONTINUE READING