Immunological disturbances in patients with premature ovarian failure.

  title={Immunological disturbances in patients with premature ovarian failure.},
  author={F. Pekonen and Rita Siegberg and T. M{\"a}kinen and Aaro Miettinen and O Yli-Korkala},
  journal={Clinical endocrinology},
  volume={25 1},
Eighteen patients with postmenopausal gonadotrophin levels and secondary amenorrhoea before the age of 35 years (premature ovarian failure, POF) were examined for the presence of cellular and humoral immune defects. Six patients had an abnormally low natural killer (NK) cell activity. The levels of circulating immune complexes were increased in six patients. Tissue antibodies were detected in six patients and two of these possessed ovarian antibodies. Leukocyte migration inhibition in the… CONTINUE READING