Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.

@article{Tan2012ImmunologicalDO,
  title={Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.},
  author={Yaohong Tan and Fernando Cruz-Guilloty and Carlos A. Medina-Mendez and Nicholas J. Cutrufello and Rosa E. Martinez and Maitee Urbieta and David Wilson and Yiwen Li and V{\'i}ctor L. P{\'e}rez},
  journal={Journal of immunology},
  year={2012},
  volume={188 12},
  pages={5962-9}
}
Corneal transplantation is the most common solid organ transplantation. The immunologically privileged nature of the cornea results in high success rates. However, T cell-mediated rejection is the most common cause of corneal graft failure. Using antiangiogenesis treatment to prevent corneal neovascularization, which revokes immune privilege, prevents corneal allograft rejection. Endostatin is an antiangiogenic factor that maintains corneal avascularity. In this study, we directly test the role… CONTINUE READING

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