Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome.

@article{Bhatia2009ImmunologicalDO,
  title={Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome.},
  author={Kishor Bhatia and James J Goedert and Rama V. Modali and Liliana R. Preiss and Leona W. Ayers},
  journal={International journal of cancer},
  year={2009},
  volume={127 6},
  pages={
          1493-6
        }
}
Dear Editor, MCPyV, a new human oncogenic polyoma virus, appears etiologic for the classic, rare, aggressive Merkel Cell Carcinomas (MCC) of the skin characterized by MCPyV DNA integration, high virus copy numbers, expression of the potentially transforming MCPyV large T antigen (LTA) evidenced by reactivity to monoclonal antibody CM2B4, signature mutations in LTA, expression of retinoblastoma protein and a vigorous MCPyV specific neutralizing antibody response. Prevalence of this MCC phenotype… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Similar Papers

Loading similar papers…