Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues.

@article{Drje1991ImmunologicalDO,
  title={Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues.},
  author={F D{\"o}rje and Allan I. Levey and Mark R. Brann},
  journal={Molecular pharmacology},
  year={1991},
  volume={40 4},
  pages={459-62}
}
Employing subtype-specific antisera, we have measured the relative levels of five muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Immunoprecipitation assays demonstrated the presence of four distinct receptor proteins (m1-m4), which showed notable differences in their tissue distribution. Significant amounts of m5 receptors were not detected in any of the tissues examined. High levels of m1 receptors were found in sympathetic ganglia and submaxillary gland. The m1… CONTINUE READING

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