Immunological detection of a novel advanced glycation end-product.

  title={Immunological detection of a novel advanced glycation end-product.},
  author={Masayoshi Takeuchi and Yuri Yanase and Nariaki Matsuura and S Yamagishi Si and Yukihiko Kameda and Richard Bucala and Zenji Makita},
  journal={Molecular medicine},
  volume={7 11},
BACKGROUND The advanced stage of the Maillard reaction that leads to the formation of advanced glycation end-products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients and in the aging process. Recently, it has been proposed that the intermediates contributing to AGE formation include dicarbonyl intermediates such as glyoxal, methylglyoxal, and 3-deoxyglucosone (3-DG). In the present study, we developed a novel, non-carboxymethyllysine (CML) anti-AGE antibody… CONTINUE READING


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