Immunological characterization of the low molecular weight gag gene proteins p19 and p15 of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of human natural antibodies to them.

@article{Kalyanaraman1984ImmunologicalCO,
  title={Immunological characterization of the low molecular weight gag gene proteins p19 and p15 of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of human natural antibodies to them.},
  author={Vaniambadi S. Kalyanaraman and M Jarvis-Morar and Mangalasseril G Sarngadharan and Robert C. Gallo},
  journal={Virology},
  year={1984},
  volume={132 1},
  pages={61-70}
}
Small molecular weight gag gene proteins p19 and p15 of human T-cell leukemia virus (HTLV) were purified to homogeneity from density banded virus, using differential affinities to phosphocellulose at pH 7.9 and 6.5. Using specific radioimmunoassays, p19 and p15 were shown to band with HTLV on sucrose gradients. These proteins were present only in HTLV-I and in cell lines expressing HTLV-I. They were not expressed in a B-cell line from patient CR, although his T cells were HTLV producers. No… CONTINUE READING
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