Immunological castration of male mice by a totally synthetic vaccine administered in saline.

@article{Carelli1982ImmunologicalCO,
  title={Immunological castration of male mice by a totally synthetic vaccine administered in saline.},
  author={Claude Carelli and Françoise Audibert and Jean-michel Gaillard and Louis Chedid},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 17},
  pages={5392-5}
}
It had been reported that immunological neutralization of the hypothalamic luteinizing hormone-releasing hormone (LH-RH) can be achieved by injection of the synthetic hormone, a decapeptide, linked to a carrier and administered with Freund's complete adjuvant. Data presented here demonstrate that the resulting immunological castration can be obtained by administering in an aqueous medium the synthetic decapeptide directly conjugated to the synthetic immunomodulator glycopeptide N-acetylmuramyl… CONTINUE READING

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