Immunological aspects of implantation and implantation failure.

  title={Immunological aspects of implantation and implantation failure.},
  author={Peter W M Johnson and Stephen E Christmas and Gill S Vince},
  journal={Human reproduction},
  volume={14 Suppl 2},
The human endometrium contains a significant proportion of leukocytes (8-35% of all cells), the absolute numbers and proportions varying during both the menstrual cycle and early in pregnancy. T cells, macrophages and a population of phenotypically unusual large granular lymphocytes (LGL) are commonly present, although B cells are absent. Relative T cell numbers decrease significantly in first trimester decidua, and hence are unlikely to play an important role in maintenance of human pregnancy… CONTINUE READING