Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy.

@article{AbdelHady2001ImmunologicalAV,
  title={Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy.},
  author={E. S. Abdel-Hady and Pierre Leonard Martin-Hirsch and Margaret Duggan-Keen and Peter L. Stern and Jim Moore and Gerald Corbitt and Henry Charles Kitchener and Ian Noel Hampson},
  journal={Cancer research},
  year={2001},
  volume={61 1},
  pages={192-6}
}
Topical 5-aminolevulinic acid-based photodynamic therapy (PDT) has produced complete response rates of >90% for nonmelanoma skin carcinomas, which are mostly human papillomavirus (HPV) negative. Using a similar treatment protocol, we observed a short-term response in only one third (10 of 32) of high-grade vulval intraepithelial neoplasia (VIN 2-3) lesions. Unifocal lesions were found more responsive than multifocal and pigmented lesions. Animal model studies have suggested that long-term PDT… CONTINUE READING

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