Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder

@inproceedings{Duffy2014ImmunologicalAN,
  title={Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder},
  author={Anne Duffy and Julie Horrocks and Steve Doucette and Charles Donald George Keown-Stoneman and Paul Grof and Ana C Andreazza and Lionel Trevor Young},
  booktitle={International journal of bipolar disorders},
  year={2014}
}
Bipolar disorder is a highly heritable illness that onsets in adolescence and young adulthood. We examined gene expression (mRNA) and protein levels of candidate immune and neurotrophic markers in well-characterized offspring of bipolar parents in order to identify reliable indicators of illness risk status and the early clinical stages of illness development. We measured mRNA expression and protein levels in candidate immune (TNF-α, IL-1β, IL-10, IFN-δ) and neurotrophic (brain-derived… CONTINUE READING
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