Immunological and clinical effects of post-transplant G-CSF versus placebo in T-cell replete allogeneic blood transplant patients: results from a randomized double-blind study.

@article{Joshi2003ImmunologicalAC,
  title={Immunological and clinical effects of post-transplant G-CSF versus placebo in T-cell replete allogeneic blood transplant patients: results from a randomized double-blind study.},
  author={Shantaram S. Joshi and Michael R. Bishop and James C. Lynch and Stefano R. Tarantolo and Sunil H Abhyankar and Philip Jay Bierman and Julie Marie Vose and Robert B. Geller and JP McGuirk and James M Foran and Robert Gregory Bociek and Abdul Hadi and Suzanne D Day and James Olen Armitage and Anne M Kessinger and Z Steven Pavletic},
  journal={Cytotherapy},
  year={2003},
  volume={5 6},
  pages={542-52}
}
BACKGROUND Immunological and clinical effects of post-transplant growth factor administration have not been well studied. This report describes the outcome and immune functions of a total of 50 HLA-matched related donor allogeneic blood stem-cell transplantation patients who received post-transplant G-CSF (10 microg/kg) or placebo. METHODS Immune status, including number of lymphocyte subsets and their functions, and serum immunoglobulin levels and clinical status--including GvHD, rate of… CONTINUE READING