Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients.


Metronomic chemotherapy stimulates the immune response via depletion of regulatory T cells (Tregs) and suppresses angiogenesis by modulating the secretion of thrombospondin-1 (TSP-1) and vascular endothelial growth factor (VEGF). In this study, blood was collected from 10 healthy dogs and from 30 canine cancer patients before and 2 and 4 weeks after… (More)
DOI: 10.1111/vco.12203


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