Immunological adjuvants promote activated T cell survival via induction of Bcl-3

@article{Mitchell2001ImmunologicalAP,
  title={Immunological adjuvants promote activated T cell survival via induction of Bcl-3},
  author={Thomas C. Mitchell and David A Hildeman and Ross M. Kedl and T Kent Teague and Brian C. Schaefer and Janice M. White and Yanan Zhu and John W. Kappler and Philippa Marrack},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={397-402}
}
Injection of soluble protein antigen into animals causes abortive proliferation of the responding T cells. Immunological adjuvants boost T cell responses at least in part by increasing the survival of activated T cells during and after the initial proliferative phase of their clonal expansion. To understand how adjuvants promote T cell survival, we used gene microarrays to analyze gene expression in T cells activated either with antigen alone or in the presence of two different adjuvants. Among… CONTINUE READING