Immunological Studies concerning the Nephritis of Systemic Lupus Erythematosus

  title={Immunological Studies concerning the Nephritis of Systemic Lupus Erythematosus},
  author={David Koffler and Peter H. Schur and Henry G. Kunkel},
  journal={The Journal of Experimental Medicine},
  pages={607 - 624}
Antibodies were eluted from the isolated glomeruli prepared from the kidneys of 10 patients with the nephritis of systemic lupus erythematosus. Antibodies reacting primarily with buffer extracts of nuclei were eluted by acid treatment, and antibodies reacting mainly with DNA and nucleoprotein were eluted with deoxyribonuclease. Quantitative immunochemical studies revealed a high concentration of antinuclear antibody per milligram of gamma-globulin in glomerular eluates compared with that in the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
120 Citations
18 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 120 extracted citations


Publications referenced by this paper.
Showing 1-10 of 18 references

Immunopathologic studies of systemic lupus erythematosus. II. Anti-nuclear reaction of T globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis

  • C. Krishman, M. H. Kaplan
  • Y. CIin. Invest
  • 1967

Anti-nuclear activity in acid eluates of glomeruli from lupus nephritis kidneys

  • C. Krishman, M. H. Kaplan
  • 1966

Elution of glomerular-bound antibody in systemic lupus erythematosus

  • M. Graf, D. Koffier
  • 1966

Estimations of the second component and third component complex of complement in the serum of patients with systemic lupus erythematosus

  • A. S. Townes, C. R. Stewart
  • Bull. Johns Hopkins Hosp. 117:348
  • 1965

Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus

  • F. Paronetto, D. Koffier
  • Clin. Invest
  • 1965

Similar Papers

Loading similar papers…