Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti‐CTLA‐4 Therapy to Inhibit Cancer Metastasis

  title={Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti‐CTLA‐4 Therapy to Inhibit Cancer Metastasis},
  author={Chao Wang and Ligeng Xu and Chao Liang and Jian Xiang and Rui Peng and Zhuang Liu},
  journal={Advanced Materials},
Photothermal ablation of primary tumors with single-walled carbon nanotubes is demonstrated to be able to trigger significant adaptive immune responses, which are not observed if tumors are removed by surgical resection. Such a treatment in combination with anti-CTLA-4 antibody therapy is able to prevent the development of tumor metastasis, which is a major cause of cancer death. 

Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle

A novel therapeutic strategy that combines adjuvant black phosphorus nanoparticle-based photoacoustic (PA) therapy with checkpoint-blockade immunotherapy that offers precise eradication of the primary tumor and can induce long-term tumor-specific immunity.

Nanomaterial-Based Tumor Photothermal Immunotherapy

  • Peng XuF. Liang
  • Biology, Chemistry
    International journal of nanomedicine
  • 2020
The mechanism and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response are summarized and when used in combination with immunotherapy, the efficacy can be improved.

Plasmonic gold nanostars for synergistic photoimmunotherapy to treat cancer

An overview of the research activities on the SYMPHONY therapy with plasmonic GNS for cancer treatment is provided.

Combining Photothermal‐Photodynamic Therapy Mediated by Nanomaterials with Immune Checkpoint Blockade for Metastatic Cancer Treatment and Creation of Immune Memory

Nanomaterial‐mediated photothermal‐photodynamic therapy in combination with ICIs are analyzed, focusing on their ability to modulate T cell populations leading to an anti‐metastatic abscopal effect and on their capacity to generate immune memory that prevents tumor recurrence.

Targeted Single-Walled Carbon Nanotubes for Photothermal Therapy Combined with Immune Checkpoint Inhibition for the Treatment of Metastatic Breast Cancer

The selective near-infrared photothermal ablation of primary orthotopic EMT6 breast tumors in syngeneic BALB/cJ mice using an annexin A5 (ANXA5) functionalized SWCNT bioconjugate synergistically enhances an anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4)-dependent abscopal response, resulting in an increased survival at 100 days after tumor inoculation.

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy, which offers a strong immunological memory effect, which can provide protection against tumour rechallenging post elimination of their initial tumours.



Controlling melanoma at local and systemic levels: is a combination of ablative therapy and immunotherapy the way forward?

It is posited that local cancer treatments can be combined with nanoparticle-delivered immune therapies to generate systemic immune responses and treat metastatic disease.

Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.

Although cryoablation is currently used to treat a targeted tumor nodule, the results suggest that combination therapy with CTLA-4 blockade will augment antitumor immunity and rejection of tumor metastases in this setting.

In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes.

In vivo obliteration of solid malignant tumors by the combined treatments of SWNTs and NIR irradiation is demonstrated and suggests that SW NTs may potentially serve as an effective photothermal agent and pave the way to future cancer therapeutics.

Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes

This study demonstrates the specific binding of antibody-coupled CNTs to tumor cells in vitro, followed by their highly specific ablation with NIR light.

Abrogation of local cancer recurrence after radiofrequency ablation by dendritic cell-based hyperthermic tumor vaccine.

Analysis of the underlying mechanism revealed that splenocytes from mice treated with HT-DC plus RFA contained significantly more tumor-specific, IFN-gamma-secreting T cells compared with control groups, suggesting the optimal priming for the DC vaccination before RFA is important for boosting antigen-specific T cell responses and prevention of cancer recurrence.

Multiwalled Carbon Nanotubes Interact with Macrophages and Influence Tumor Progression and Metastasis

Investigation of the influences of oxidized multiwalled carbon nanotubes on macrophages in the normal subcutis tissue or in the tumor microenvironment in vivo as well as on the macrophage cell line of RAW 264.7 showed that subcutaneously injected o-MWCNT not only induced phagocytosis of the local residentmacrophages, but also competitively recruited macrophaged from other tissues.

Drug delivery with carbon nanotubes for in vivo cancer treatment.

In vivo SWNT drug delivery for tumor suppression in mice shows nanotube drug delivery is promising for high treatment efficacy and minimum side effects for future cancer therapy with low drug doses.

In Situ Tumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity

It is demonstrated that following RFA, a weak but detectable immune response develops, directed against OVA, but also against a broader range of B16 antigens, and this strongly enhanced antitumor immunity, resulting in long-lasting tumor protection.