Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo

@article{Takeuchi2000ImmunologicalET,
  title={Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo},
  author={Masayoshi Takeuchi and Zenji Makita and Richard Bucala and Takashige Suzuki and Terumoto Koike and Yukihiko Kameda},
  journal={Molecular Medicine},
  year={2000},
  volume={6},
  pages={114-125}
}
BackgroundThe Maillard reaction that leads to the formation of advanced glycation end-products (AGE) plays an important role in the pathogenesis of angiopathy in diabetic patients and in the aging process. Recently, it was proposed that AGE were not only created by glucose, but also by dicarbonyl compounds derived from the Maillard reaction, autoxidation of sugars and other metabolic pathways of glucose. In this study, we developed four types of non-carboxymethyllysine (CML) anti-AGE antibodies… CONTINUE READING
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