Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans

@article{Schountz2017ImmunologicalCO,
  title={Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans},
  author={Tony Schountz and Michelle L. Baker and J. Russell Butler and Vincent J. Munster},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
Bats are reservoir hosts of many important viruses that cause substantial disease in humans, including coronaviruses, filoviruses, lyssaviruses, and henipaviruses. Other than the lyssaviruses, they do not appear to cause disease in the reservoir bats, thus an explanation for the dichotomous outcomes of infections of humans and bat reservoirs remains to be determined. Bats appear to have a few unusual features that may account for these differences, including evidence of constitutive interferon… 
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Constitutive IFNα protein production in bats
TLDR
A unique IFN response in bat species that may explain their ability to coexist with multiple viruses in the absence of pathology is confirmed and may help to manage potential zoonotic viral reservoirs and potentially identify new anti-viral strategies.
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