Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.

@article{Sakaguchi2001ImmunologicTM,
  title={Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.},
  author={Shimon Sakaguchi and Noriko Sakaguchi and Jun Shimizu and Sayuri Yamazaki and Toshiko Sakihama and Mizue Itoh and Yoshio Kuniyasu and Takashi Nomura and Masaaki Toda and Takeshi Takahashi},
  journal={Immunological reviews},
  year={2001},
  volume={182},
  pages={18-32}
}
There is accumulating evidence that T-cell-mediated dominant control of self-reactive T-cells contributes to the maintenance of immunologic self-tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T-cell population have revealed that CD25+ cells in the CD4+ population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro. The… CONTINUE READING