Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.

@article{Miedema1985ImmunologicSW,
  title={Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.},
  author={Frank A Miedema and Pedro A. T. Tetteroo and F G Terpstra and G. de Keizer and Micha Roos and Ron S. Weening and Corry MR Weemaes and David A. Roos and Cornelis J M Melief},
  journal={Journal of immunology},
  year={1985},
  volume={134 5},
  pages={3075-81}
}
A patient and his parents, deficient for lymphocyte function associated antigen-1 (LFA-1) and Mo1 (OKM1), were studied with respect to leukocyte surface marker expression and functional properties. The patient had a history of severe recurrent bacterial infections. Two siblings had already died of bacterial infections. The patient's granulocytes, monocytes, and lymphocytes expressed low but detectable amounts (less than or equal to 10%) of LFA-1 and Mo1. Intracellularly, LFA-1 and Mo1 (OKM1… CONTINUE READING
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