Immunologic studies of rheumatoid arthritis patients treated with methotrexate.

@article{Olsen1987ImmunologicSO,
  title={Immunologic studies of rheumatoid arthritis patients treated with methotrexate.},
  author={Nancy J Olsen and Leigh F. Callahan and Theodore Pincus},
  journal={Arthritis and rheumatism},
  year={1987},
  volume={30 5},
  pages={481-8}
}
Immunologic functions of peripheral blood mononuclear cells were studied in rheumatoid arthritis (RA) patients treated with methotrexate (MTX). Spontaneous IgM rheumatoid factor (IgM-RF) synthesis by unstimulated cultured blood mononuclear cells was seen in only 3 of 18 MTX-treated patients, compared with 31 of 54 RA patients who were not receiving long-acting drugs. Total IgM production by unstimulated cultured mononuclear cells, pokeweed mitogen-induced antibody synthesis, and plasma levels… CONTINUE READING