Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods: isoimmune, Wassermann, and autoimmune reactions.

@article{Kaplan1961ImmunologicSO,
  title={Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods: isoimmune, Wassermann, and autoimmune reactions.},
  author={Melvin H. Kaplan and Mary Meyeserian and Irving Kushner},
  journal={Journal of Experimental Medicine},
  year={1961},
  volume={113},
  pages={17-36}
}
Reactions of normal and pathologic sera with heart tissue have been investigated by the immunofluorescent method, with particular reference to presumptive autoantibodies to heart and their differentiation from blood group isoantibodies and Wassermann antibody. In the heart, blood group substances A and B were found distributed in capillary walls, vascular endothelium, and interstitial connective tissue. In surveys of randomly selected sera, isoimmune reactions against tissue blood group… 
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.
TLDR
The immunologic relationship between streptococcal cell wall antigen and myofibers and smooth muscle of vessel walls is consistent with the hypothesis that bound γ-globulin observed in rheumatic hearts in these sites is derived from immune bodies.
AUTOANTIBODIES TO HEART AND RHEUMATIC FEVER: THE INDUCTION OF AUTOIMMUNITY TO HEART BY STREPTOCOCCAL ANTIGEN CROSS‐REACTIVE WITH HEART *
  • M. H. Kaplan
  • Medicine, Biology
    Annals of the New York Academy of Sciences
  • 1965
TLDR
In the above studies, serologic reaction with heart tissue components was demonstrated by a variety of techniques, including complement fixation, collodion particle agglutination, tanned-cell hemagglutinations, immunofluorescence, and antiglobulin consumption.
Chagasic Cardiopathy: Demonstration of a Serum Gamma Globulin Factor Which Reacts with Endocardium and Vascular Structures
TLDR
In almost all cases studied, the EVI factor of the serum results in a negative reaction, suggesting that the genesis of the reacting gamma globulin is related to antigens of T. cruzi, suggesting the diagnosis of chronic chagasic cardiopathy can be considered with a low probability in the absence of this factor.
Antigenic composition of heart tissue.
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS
TLDR
Sera from patients with recent streptococcal infection or non-suppurative sequelae exhibit with variable frequency a precipitin reaction in agar gel with a partially purified strePTococcal antigen, providing evidence that induction of cross-reactive autoantibody to heart in certain individuals is associated with streptitiscal infection.
Antibodies in the sera of acute rheumatic fever patients bind to human cardiac tropomyosin.
TLDR
A comparison of the N-terminal sequence of the purified protein and competitive inhibition assays indicated that the reactive sarcolemmal antigen was human cardiac tropomyosin, which was confirmed to be heart reactive antibodies.
antigens . variety of cardiac , nuclear , and streptococcal Rheumatic fever : autoantibodies against a
TLDR
It is demonstrated that there is an exaggerated humoral response to several cardiac, nuclear and streptococcal antigens in patients with rheumatic fever.
Rheumatic fever: autoantibodies against a variety of cardiac, nuclear, and streptococcal antigens.
TLDR
It is demonstrated that there is an exaggerated humoral response to several cardiac, nuclear and streptococcal antigens in patients with rheumatic fever.
HEART–REACTIVE ANTIBODIES IN RHEUMATIC FEVER
Antibodies reacting with mammalian heart tissue were detected by immunofluorescence in 84% of sera taken from 37 patients with rheumatic fever and in 76% of 37 patients with uncomplicated
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The concept that the myocardial Aschoff bodies of rheumatic fever are induced by repeated infections with group A streptococci of several different serological types is supported, even though only a certain few among the many patients so infected develop these lesions.
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    Annals of the New York Academy of Sciences
  • 1960
TLDR
The investigation reported in this paper was supported in part by Research Grant H3726 from the National Heart Institute, Public Health Service, Bethesda, Md., and by a grant-in-aid from the Cleveland Foundation, Cleveland, Ohio.
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TLDR
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