Immunologic significance of a collagen-derived culture filtrate containing proteolytic activity in Aspergillus-related diseases.

@article{Tomee1994ImmunologicSO,
  title={Immunologic significance of a collagen-derived culture filtrate containing proteolytic activity in Aspergillus-related diseases.},
  author={J F C Tomee and Henk F. Kauffman and Alida H. Klimp and Jan G R de Monchy and Gerard H. Ko{\"e}ter and A E J Dubois},
  journal={The Journal of allergy and clinical immunology},
  year={1994},
  volume={93 4},
  pages={768-78}
}
BACKGROUND Despite increasing evidence implicating fungal proteases in the virulence of pulmonary fungal diseases, routine fungal culture media do not favor protease production. Hence, filtrates that serve as the source of antigen for serologic determinations are poor in proteases, and consequently, the immunologic significance of these enzymes is unknown. METHODS A clinical isolate of Aspergillus fumigatus was cultured on collagen medium, resulting in excretion of high levels of fungal… CONTINUE READING

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