Immunologic memory to PC-KLH: participation of the Q52 VH gene family.

@article{StenzelPoore1987ImmunologicMT,
  title={Immunologic memory to PC-KLH: participation of the Q52 VH gene family.},
  author={Mary P. Stenzel-Poore and Tony J. Hall and Christoph H. Heusser and C H Faust and Marvin B. Rittenberg},
  journal={Journal of immunology},
  year={1987},
  volume={139 5},
  pages={1698-703}
}
BALB/c mice immunized with phosphocholine-conjugated keyhole limpet hemocyanin respond with two major groups of antibodies that differ with respect to fine specificity and idiotype. Group I antibodies predominantly bear the T15 idiotype, and show appreciable affinity for the haptens PC and nitrophenyl PC (NPPC), whereas group II antibodies have appreciable affinity for NPPC only and are T15 idiotype negative. Previous studies indicated that group II binding characteristics may derive from the… CONTINUE READING