Immunologic mediator release from rhesus and cynomolgus monkey lung.

@article{Weichman1980ImmunologicMR,
  title={Immunologic mediator release from rhesus and cynomolgus monkey lung.},
  author={Barry M. Weichman and Linda S. Hostelley and Sheila P. Bostick and Lawrence William Chakrin},
  journal={Journal of pharmacological methods},
  year={1980},
  volume={4 1},
  pages={
          59-69
        }
}
Abstract Histamine and slow reacting substance of anaphylaxis (SRS-A) were evoked from fragmented rhesus and cynomolgus monkey lung in a reverse-type anaphylactic reaction with anti-human IgE. Rhesus lung tissue passively sensitized in vitro with high titer IgE human serum released 11.6 ± 0.5% of the total tissue histamine ( n = 139) and 246 ± 26 units SRS-A g tissue ( n = 104). Interestingly, lung tissue not passively sensitized released significant amounts of both mediators upon challenge… 
1 Citations
SK&F 104353, a selective leukotriene receptor antagonist, inhibits leukotriene D4- and antigen-induced bronchoconstriction in cynomolgus monkeys.
TLDR
The data suggest that LTs, in addition to histamine, play a role in allergic bronchoconstriction in cynomolgus monkeys.

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