Immunologic hurdles of therapeutic stem cell transplantation.

  title={Immunologic hurdles of therapeutic stem cell transplantation.},
  author={Olaf Utermoehlen and Nikola Baschuk and Zeinab Abdullah and A. M. Engelmann and Udo Siebolts and Claudia Wickenhauser and Carol B. Stocking and M D Kurt Kroenke},
  journal={Biological chemistry},
  volume={390 10},
Detailed knowledge of the immunologic properties of embryonic stem (ES) cells is a prerequisite for safe applications of ES cell-based regenerative medicine. Recently, the long-standing assumption that ES cells are ignored by immunocompetent hosts was disproved. Instead, it is becoming increasingly clear that ES cells actively protect themselves via several immunomodulatory and immunoevasive mechanisms against cytotoxic T-lymphocytes and natural killer cells. Here we review current knowledge… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 45 references

Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007
View 4 Excerpts
Highly Influenced

Human embryonic stem cells possess immune-privileged properties.

Stem cells • 2004
View 4 Excerpts
Highly Influenced

Trophoblast immune receptors in maternal-fetal tolerance.

Immunological investigations • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…