Immunologic hurdles of therapeutic stem cell transplantation.

@article{Utermoehlen2009ImmunologicHO,
  title={Immunologic hurdles of therapeutic stem cell transplantation.},
  author={Olaf Utermoehlen and Nikola Baschuk and Zeinab Abdullah and A. M. Engelmann and Udo Siebolts and Claudia Wickenhauser and Carol B. Stocking and M D Kurt Kroenke},
  journal={Biological chemistry},
  year={2009},
  volume={390 10},
  pages={977-83}
}
Detailed knowledge of the immunologic properties of embryonic stem (ES) cells is a prerequisite for safe applications of ES cell-based regenerative medicine. Recently, the long-standing assumption that ES cells are ignored by immunocompetent hosts was disproved. Instead, it is becoming increasingly clear that ES cells actively protect themselves via several immunomodulatory and immunoevasive mechanisms against cytotoxic T-lymphocytes and natural killer cells. Here we review current knowledge… CONTINUE READING

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