Immunologic heterogeneity of tumor cell subpopulations from a single mouse mammary tumor.

@article{Miller1979ImmunologicHO,
  title={Immunologic heterogeneity of tumor cell subpopulations from a single mouse mammary tumor.},
  author={F. Roy Miller and Gloria H. Heppner},
  journal={Journal of the National Cancer Institute},
  year={1979},
  volume={63 6},
  pages={1457-63}
}
Five subpopulations (66, 67, 68H, 168, and 4.10LM) obtained from a single BALB/cfC3H mammary adenocarcinoma were used to assess intratumor immunologic heterogeneity. BALB/c and BALB/cfC3H mice were immunized with each of the subpopulations, and lymph node cells (LNC) from immunized animals were tested for cell-mediated immunity (CMI) to each subpopulation in vitro by chromium release and microcytotoxicity tests and in vivo by Winn assays. The immunogenic character of the subpopulations differed… CONTINUE READING

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