Immunologic evidence that the properties of human antihemophilic factor (factor VIII) are attributes of a single molecular species.

Abstract

Preparations of human plasma rich in antihemophilic factor (AHF, factor VIII) correct the coagulative defect of classic hemophilic plasma, form precipitates with specific heterologous antiserum, and support aggregation of platelets by ristacetin and retention of platelets by columns of glass beads. Whether these various properties can all be attributed to a… (More)

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