Immunologic correlates of protection induced by vaccination.

@article{Plotkin2001ImmunologicCO,
  title={Immunologic correlates of protection induced by vaccination.},
  author={Stanley A. Plotkin},
  journal={The Pediatric infectious disease journal},
  year={2001},
  volume={20 1},
  pages={
          63-75
        }
}
Vaccine design and licensing depend on the choice of protective antigens and the demonstration of their efficacy. Ideally efficacy correlates with some measurement of immune response, although occasionally the correlation is weak and in the case of some vaccines uncertain. This paper attempts to review what is known about correlates of vaccine-induced protection. Although mucosal and cellular immune responses are clearly important to protection by some vaccines, most vaccines licensed today… CONTINUE READING
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