Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

@article{Rosenberg1998ImmunologicAT,
  title={Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma},
  author={Steven A Rosenberg and James C Yang and Douglas J. Schwartzentruber and Patrick Hwu and Francesco M. Marincola and Suzanne Louise Topalian and Nicholas P Restifo and Mark Edward Dudley and Susan L. Schwarz and Paul J. Spiess and Maria R. Parkhurst and Yutaka Kawakami and Claudia A. Seipp and Jan H. Einhorn and Donald E. White},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={321-327}
}
The cloning of the genes encoding cancer antigens has opened new possibilities for the treatment of patients with cancer. In this study, immunodominant peptides from the gp100 melanoma-associated antigen were identified, and a synthetic peptide, designed to increase binding to HLA-A2 molecules, was used as a cancer vaccine to treat patients with metastatic melanoma. On the basis of immunologic assays, 91% of patients could be successfully immunized with this synthetic peptide, and 13 of 31… CONTINUE READING
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